| School | Pos | Player | Injury | Status |
| Arizona State | RB | Dimitri Nance | Shoulder | Questionable |
| Arizona State | QB | Danny Sullivan | Knee | Questionable |
| Arkansas | RB | Michael Smith | Hamstring | Questionable |
| Arkansas | WR | Joe Adams | Mild stroke | Out |
| Ball State | QB | Kelly Page | Thumb, out for year | Out |
| Buffalo | RB | Brandon Thermilus | Ankle injury | Questionable |
| BYU | WR | McKay Jacobson | Hamstring, out 4-6 weeks | Questionable |
| Cincinnati | QB | Tony Pike | Wrist | Questionable |
| Clemson | RB | C.J. Spiller | Toe | Probable |
| Colorado State | RB | Leonard Mason | Ribs | Questionable |
| East Carolina | RB | Dominique Lindsay | Ankle | Questionable |
| Hawaii | QB | Bryant Moniz | Concussion | Questionable |
| Iowa | RB | Adam Robinson | Ankle, out for season | Out |
| Iowa State | RB | Alexander Robinson | Nagging groin and shoulder injuries | Questionable |
| Iowa State | QB | Austen Arnaud | Bruised throwing hand | Questionable |
| Kansas | RB | Jake Sharp | Calf, played last week | Probable |
| Kentucky | WR | Randall Cobb | Knee | Questionable |
| Kentucky | QB | Derrick Locke | MCL strain | Questionable |
| La-Lafayette | RB | Undrea Sails | Leg fracture, out for year | Out |
| La-Monroe | QB | Trey Revell | Broken thumb | Out |
| Louisville | RB | Victor Anderson | Bone bruise on leg | Probable |
| Marshall | RB | Darius Marshall | Knee bruise | Probable |
| Maryland | RB | Da’Rel Scott | Broken wrist, out 5 weeks | Out |
| Michigan State | QB | Keith Nichol | Elbow | Questionable |
| Minnesota | WR | Eric Decker | Foot, out for season | Out |
| Missouri | QB | Blaine Gabbert | Ankle | Probable |
| Navy | QB | Ricky Dobbs | Knee | Questionable |
| Navy | RB | Marcus Curry | Quadriceps | Questionable |
| Nebraska | RB | Roy Helu | Shoulder | Probable |
| North Texas | QB | Riley Dodge | Ankle | Doubtful |
| Northern Illinois | QB | Chandler Harnish | Knee | Out |
| Notre Dame | WR | Michael Floyd | Collarbone, could return in November | Out |
| Ohio State | RB | Boom Herron | Ankle sprain | Questionable |
| Ohio State | RB | Brandon Saine | Concussion | Questionable |
| Oklahoma | RB | Demarco Murray | Ankle | Probable |
| Oklahoma State | WR | Dez Bryant | Eligibility issues | Out |
| Oklahoma State | RB | Kendall Hunter | Leg | Questionable |
| Oregon State | WR | James Rodgers | Knee | Probable |
| Oregon State | RB | Jacquizz Rodgers | Ankle | Probable |
| San Diego State | WR | Vincent Brown | Hand | Questionable |
| SMU | QB | Bo Levi Mitchell | Shoulder | Questionable |
| South Carolina | QB | Stephen Garcia | Knee | Probable |
| South Carolina | WR | Moe Brown | Concussion | Out |
| Syracuse | WR | Mike Williams | Suspension, expected to play | Probable |
| Texas A&M | WR | Jeff Fuller | Leg, played sparingly last week | Probable |
| Texas Tech | QB | Steven Sheffield | Foot | Out |
| Toledo | QB | Aaron Opelt | Shoulder | Questionable |
| Toledo | QB | Austin Dantin | Ankle | Questionable |
| Troy | PK | Sam Glusman | Quad | Questionable |
| UAB | WR | Frantrell Forrest | Undisclosed knee injury | Questionable |
| USC | TE | Anthony McCoy | Sprained Ankle | Questionable |
| Western Michigan | WR | Jordan White | Ankle | Questionable |
| Western Michigan | WR | Juan Nunez | Ankle | Questionable |
| Wisconsin | RB | Zach Brown | Concussion | Questionable |
