| School | Pos | Player | Injury | Status |
| Arizona | RB | Nic Grigsby | Sore shoulder | Questionable |
| Arizona State | WR | Chris McGaha | Flu | Questionable |
| Arizona State | PK | Thomas Weber | Torn groin muscle | Out |
| Arkansas | RB | Michael Smith | Hamstring, he has practiced | Probable |
| Arkansas | WR | Joe Adams | Mild stroke | Doubtful |
| Baylor | QB | Blake Szymanski | Bruised shoulder, may start 10/17 | Probable |
| BYU | WR | McKay Jacobson | Hamstring, out 4-6 weeks | Out |
| BYU | WR | Harvey Unga | Back tightness, missed practice Tuesday | Probable |
| Cincinnati | QB | Tony Pike | Broken arm, likely to miss 10/24 game | Out |
| FIU | WR | TY Hilton | Knee sprain, missed practice time | Doubtful |
| Florida Atlantic | TE | Jamari Grant | Ankle | Probable |
| Florida Atlantic | TE | Cortez Gent | Flu | Probable |
| Iowa State | RB | Alexander Robinson | Nagging groin and shoulder injuries | Probable |
| Kansas | RB | Jake Sharp | Calf | Doubtful |
| Kansas State | RB | Daniel Thomas | Knee | Questionable |
| Kentucky | QB | Mike Hartline | Undisclosed knee injury | Questionable |
| La-Monroe | QB | Trey Revell | Broken thumb | Questionable |
| La Tech | RB | Daniel Porter | Hamstring | Questionable |
| Maryland | RB | Da’Rel Scott | Broken wrist, out 5 weeks | Out |
| Memphis | QB | Tyler Bass | Shoulder | Doubtful |
| Miami(FL) | WR | Aldarius Johnson | Groin | Probable |
| Michigan | QB | Tate Forcier | Concussion | Probable |
| Michigan | RB | Carlos Brown | Concussion | Probable |
| Michigan State | QB | Keith Nichol | Elbow | Probable |
| Michigan State | RB | Larry Caper | Knee | Probable |
| Michigan State | RB | Glenn Winston | Knee | Out |
| Missouri | QB | Blaine Gabbert | Ankle | Probable |
| Nebraska | RB | Roy Helu | Shoulder | Probable |
| Nevada | RB | Vai Taua | Dislocated elbow | Probable |
| North Texas | RB | Cam Montgomery | Hamstring | Questionable |
| Notre Dame | WR | Michael Floyd | Collarbone, could return in November | Out |
| Ohio State | RB | Boom Herron | Ankle sprain | Questionable |
| Oklahoma | WR | Ryan Broyles | Broken shoulder blade | Questionable |
| Oklahoma State | WR | Dez Bryant | Eligibility issues | Out |
| Oklahoma State | RB | Kendall Hunter | Leg | Questionable |
| Oregon | QB | Jeremiah Masoli | Knee | Questionable |
| SMU | RB | Shawnbrey McNeal | Back injury | Probable |
| South Carolina | TE | Weslye Saunders | Sprained ankle | Probable |
| Southern Miss | QB | Austin Davis | Knee | Out |
| Texas A&M | WR | Jeff Fuller | Broken fibula, has begun to practice again | Questionable |
| Texas Tech | QB | Taylor Potts | Concussion | Questionable |
| Toledo | QB | Aaron Opelt | Shoulder | Questionable |
| Tulane | RB | Andre Anderson | Minor shoulder injury | Probable |
| UAB | WR | Frantrell Forrest | Undisclosed knee injury | Probable |
| UL-Lafayette | QB | Chris Masson | Knee | Probable |
| Virginia | RB | Mikell Simpson | Neck | Questionable |
| Wisconsin | RB | Zach Brown | Concussion | Out |
