| School | Pos | Player | Injury | Status |
| Air Force | QB | Tim Jefferson | Sprained ankle | Probable |
| Arizona | RB | Keola Antolin | Sprained ankle | Questionable |
| Arizona | RB | Nic Grigsby | Sprained shoulder | Questionable |
| Arizona State | PK | Thomas Weber | Torn groin muscle | Out |
| Baylor | QB | Blake Szymanski | Bruised shoulder, x-rays negative | Questionable |
| Baylor | RB | Jay Finley | Ankle, swelling | Questionable |
| Bowling Green | TE | Jimmy Scheidler | Ankle, on crutches | Questionable |
| BYU | WR | McKay Jacobson | Hamstring, out 4-6 weeks | Out |
| Clemson | RB | C.J. Spiller | Turf toe | Questionable |
| Eastern Michigan | QB | Andy Schmidt | Knee - out for year | Out |
| Florida | WR | Deonte Thompson | Hamstring | Probable |
| Florida | QB | Tim Tebow | Concussion, not yet cleared to play | Questionable |
| Florida Atlantic | TE | Jamari Grant | Ankle | Questionable |
| Hawaii | QB | Greg Alexander | Knee, out for year | Out |
| Illinois | WR | Arrelious Benn | Shoulder | Questionable |
| Iowa | TE | Tony Moeaki | Ankle sprain | Questionable |
| Iowa State | WR | Darius Reynolds | Broken Leg | Out |
| Iowa State | RB | Alexander Robinson | Re-injured his groin | Probable |
| Kansas | RB | Jake Sharp | Calf | Probable |
| Maryland | RB | Da’Rel Scott | Broken wrist, out 5 weeks | Out |
| Memphis | RB | Curtis Steele | Sprained knee | Probable |
| Memphis | QB | Tyler Bass | Shoulder | Questionable |
| Miami(FL) | WR | Aldarius Johnson | Groin | Probable |
| Michigan | RB | Brandon Minor | Ankle | Probable |
| Michigan | QB | Tate Forcier | Shoulder | Probable |
| Michigan State | RB | Edwin Baker | Knee | Probable |
| MTSU | RB | Phillip Tanner | Knee | Doubtful |
| NC State | WR | Owen Spencer | Concussion | Questionable |
| Nevada | RB | Vai Taua | Dislocated elbow | Probable |
| Northwestern | RB | Stephen Simmons | Leg | Out |
| Notre Dame | RB | Armando Allen | Ankle | Probable |
| Notre Dame | QB | Jimmy Clausen | Turf toe | Probable |
| Ohio | QB | Boo Jackson | Shoulder | Out |
| Ohio State | RB | Boom Herron | Ankle sprain | Probable |
| Oklahoma | QB | Sam Bradford | Shoulder | Questionable |
| Oklahoma | WR | Ryan Broyles | Broken shoulder blade, out 2-4 weeks | Out |
| Oklahoma State | WR | Dez Bryant | Hamstring, status update on Wed. | Questionable |
| Oklahoma State | RB | Kendall Hunter | Leg, status update on Wed. | Questionable |
| Oregon | QB | Jeremiah Masoli | Knee | Questionable |
| Oregon | RB | LaMichael James | Sparined ankle | Probable |
| Rice | QB | Nick Fanuzzi | Shoulder | Doubtful |
| Rutgers | QB | Tom Savage | Concussion | Questionable |
| South Carolina | TE | Weslye Saunders | Sprained ankle | Questionable |
| Southern Miss | WR | DeAndre Brown | Shoulder | Probable |
| Southern Miss | RB | Damion Fletcher | undisclosed injury | Probable |
| Southern Miss | QB | Austin Davis | Knee, out for year | Out |
| Texas A&M | RB | Christine Michael | Calf | Probable |
| Texas A&M | WR | Jeff Fuller | Broken fibula | Out |
| Texas Tech | QB | Taylor Potts | Concussion | Doubtful |
| UAB | WR | Frantrell Forrest | Undisclosed knee injury | BYE |
| UL-Lafayette | QB | Chris Masson | Knee | Probable |
| UNLV | QB | Omar Clayton | Shoulder soreness, gametime decision | Questionable |
| USC | RB | Stafon Johnson | Neck | Out |
| Wake Forest | TE | Ben Wooster | Back injury - bulging disc | Out |
| Washington | WR | D’Andre Goodwin | Concussion | Probable |
| Western Michigan | WR | Juan Nunez | Bruised knee | Questionable |
