| School | Pos | Player | Injury | Status |
| Air Force | QB | Tim Jefferson | Sprained ankle | Probable |
| Akron | QB | Chris Jacquemain | Suspended, done for the year | Out |
| Alabama | RB | Roy Upchurch | High ankle sprain, day-to-day | Probable |
| Arizona | TE | Rob Gronkowski | Back surgery | Out |
| Arizona | RB | Keola Antolin | Sprained ankle | BYE |
| Arizona | RB | Nic Grigsby | Sprained shoulder | BYE |
| Arizona State | PK | Thomas Weber | Torn groin muscle | Out |
| Baylor | QB | Blake Szymanski | Bruised shoulder, x-rays negative | Probable |
| Baylor | RB | Jay Finley | Ankle, swelling | Questionable |
| Baylor | QB | Robert Griffin | Torn ACL - out for year | Out |
| Boise State | RB | D.J. Harper | Torn ACL - out for year | Out |
| Bowling Green | TE | Jimmy Scheidler | Ankle, on crutches | Questionable |
| Central Michigan | RB | Bryan Schroeder | undisclosed injury | Questionable |
| Connecticut | QB | Zach Fraser | Knee | Out |
| Eastern Michigan | QB | Andy Schmidt | Knee - out for year | Out |
| FIU | TE | Dudley LaPorte | Eligibility issues | Out |
| Florida | WR | Deonte Thompson | Hamstring | BYE |
| Florida | QB | Tim Tebow | Concussion | BYE |
| Florida Atlantic | WR | Cortez Gent | Suspension, expected back | Probable |
| Florida Atlantic | TE | Jamari Grant | Ankle | Out |
| Hawaii | QB | Greg Alexander | Possible torn MCL | Out |
| Iowa | TE | Tony Moeaki | Ankle sprain | Doubtful |
| Iowa State | WR | Darius Reynolds | Broken Leg | Out |
| Iowa State | RB | Alexander Robinson | Pulled groin | Probable |
| Kansas | RB | Jake Sharp | Calf | BYE |
| UL-Lafayette | QB | Chris Masson | Knee | Probable |
| Memphis | RB | Curtis Steele | Sprained knee | Probable |
| Miami(FL) | WR | Aldarius Johnson | Groin | Probable |
| Michigan | RB | Brandon Minor | Ankle | Probable |
| Michigan | QB | Tate Forcier | Shoulder | Probable |
| Michigan State | RB | Edwin Baker | Knee | Probable |
| MTSU | RB | Phillip Tanner | Knee | BYE |
| NC State | WR | Owen Spencer | Concussion | Out |
| Nevada | RB | Vai Taua | Dislocated elbow | Out |
| North Carolina | TE | Zack Pianalto | Foot | Out |
| NC State | WR | Owen Spencer | Concussion | Questionable |
| Northwestern | RB | Stephen Simmons | Leg | Out |
| Notre Dame | RB | Armando Allen | Ankle, game-time decision | Probable |
| Notre Dame | QB | Jimmy Clausen | Turf toe | Probable |
| Notre Dame | WR | Michael Floyd | Broken collarbone | Out |
| Ohio | QB | Boo Jackson | Shoulder | Out |
| Ohio State | RB | Boom Herron | Ankle sprain, will not start | Probable |
| Oklahoma | QB | Sam Bradford | Shoulder | Out |
| Oklahoma State | WR | Dez Bryant | Hamstring | BYE |
| Oklahoma State | RB | Kendall Hunter | Leg | BYE |
| Penn State | WR | Graham Zug | Concussion | Questionable |
| Rice | QB | Nick Fanuzzi | Shoulder | Doubtful |
| Rutgers | QB | Tom Savage | Concussion | BYE |
| San Diego State | RB | Brandon Sullivan | MCL sprain | Out |
| San Diego State | RB | Atiyyah Henderson | Back | Out |
| South Carolina | QB | Stephen Garcia | Bruised hip | Probable |
| South Florida | QB | Matt Grothe | Torn ACL | Out |
| Southern Miss | RB | Tory Harrison | undisclosed injury | Probable |
| Southern Miss | WR | DeAndre Brown | Shoulder | Out |
| Southern Miss | RB | Damion Fletcher | undisclosed injury | Out |
| Tennessee | RB | Montario Hardesty | Knee drained | Probable |
| Texas | WR | Brandon Collins | Academics | Out |
| Texas A&M | RB | Christine Michael | Calf | Probable |
| Texas A&M | WR | Jeff Fuller | Broken fibula | Out |
| UAB | WR | Frantrell Forrest | Undisclosed knee injury | Out |
| UNLV | QB | Omar Clayton | Shoulder soreness, gametime decision | Probable |
| USC | RB | Stafon Johnson | Neck | Out |
| Utah | RB | Matt Asiata | Torn ACL - out for year | Out |
| Vanderbilt | RB | Zac Stacy | Ankle | Doubtful |
| Virginia | RB | Mikell Simpson | Leg injury | Probable |
| Wake Forest | TE | Ben Wooster | Back injury - bulging disc | Out |
| Washington State | RB | James Montgomery | Leg injury, done for year | Out |
