| School | Pos | Player | Injury | Status |
| Air Force | QB | Tim Jefferson | Sprained ankle | Probable |
| Akron | QB | Chris Jacquemain | Suspended, done for the year | Out |
| Alabama | RB | Roy Upchurch | High ankle sprain, day-to-day | Probable |
| Alabama | WR | Julio Jones | Bruised knee, practiced this week | Probable |
| Arizona | TE | Rob Gronkowski | Back surgery | Out |
| Arizona State | PK | Thomas Weber | Torn groin muscle | Out |
| Arkansas | RB | Michael Smith | Bruised shoulder | Probable |
| Baylor | RB | Jay Finley | Ankle, swelling | Questionable |
| Boise State | RB | D.J. Harper | Torn ACL | Out |
| Bowling Green | TE | Jimmy Scheidler | Ankle, on crutches | Questionable |
| Clemson | RB | C.J. Spiller | Turf toe | Probable |
| Connecticut | QB | Zach Fraser | Knee | Out |
| FAU | WR | Cortez Gent | Suspension | Likely out |
| FIU | QB | Paul McCall | Sprained knee | Probable |
| FIU | TE | Dudle LaPorte | Eligibility issues | Out |
| Florida | RB | Jeffrey Demps | Flu | Probable |
| Florida | WR | Deonte Thompson | Hamstring | Questionable |
| Florida | TE | Aaron Hernandez | Flu | Questionable |
| Georgia Tech | RB | Jonathan Dwyer | Shoulder | Probable |
| Illinois | QB | Juice Williams | Quadricep, should be 100% | Probable |
| Iowa | TE | Tony Moeaki | Ankle sprain | Questionable |
| Kansas | RB | Jake Sharp | Calf | Doubtful |
| Memphis | RB | Curtis Steele | Sprained knee | Out |
| Miami(FL) | WR | Aldarius Johnson | Groin | Questionable |
| Michigan | QB | Tate Forcier | Ribs | Probable |
| Michigan | RB | Brandon Minor | Ankle | Probable |
| Michigan State | RB | Edwin Baker | Knee | Doubtful |
| Minnesota | WR | Eric Decker | Ankle | Probable |
| MTSU | RB | Phillip Tanner | Knee | Out |
| NC State | WR | Owen Spencer | Concussion | Out |
| Nebraska | QB | Zac Lee | Thumb, non-throwing hand | Probable |
| Nevada | RB | Vai Taua | Elbow | Unknown |
| North Carolina | TE | Zack Pianalto | Foot | Out |
| North Texas | QB | Riley Dodge | Shoulder | Probable |
| Northwestern | RB | Stephen Simmons | Leg | Doubtful |
| Notre Dame | RB | Armando Allen | Ankle, game-time decision | Questionable |
| Notre Dame | QB | Jimmy Clausen | Turf toe | Probable |
| Notre Dame | WR | Michael Floyd | Broken collarbone | Out |
| Ohio | QB | Boo Jackson | Shoulder | Out |
| Oklahoma State | WR | Dez Bryant | Hamstring | Out |
| Oklahoma State | RB | Kendall Hunter | Leg | Doubtful |
| Penn State | WR | Graham Zug | Concussion | Questionable |
| Rice | QB | Nick Fanuzzi | Shoulder | Questionable |
| Rutgers | QB | Tom Savage | Concussion | Questionable |
| San Diego State | RB | Brandon Sullivan | MCL sprain | Out |
| San Diego State | RB | Atiyyah Henderson | Back | Out |
| South Florida | QB | Matt Grothe | Torn ACL | Out |
| Texas | RB | Vondrell McGee | Ankle | Questionable |
| Texas A&M | RB | Christine Michael | Calf, may be limited | Probable |
| Texas A&M | WR | Jeff Fuller | Broken fibula | Out |
| Troy | RB | DuJuan Harris | Knee | Questionable |
| Tulsa | RB | Charles Clay | Undisclosed injury | Questionable |
| UNLV | WR | Philip Payne | Flu | Probable |
| USC | RB | Joe McKnight | Ankle | Probable |
| USC | QB | Matt Barkley | Shoulder | Probable |
| Virginia Tech | RB | Ryan Williams | Minor ankle injury | Probable |
| Washington State | RB | James Montgomery | Leg injury, done for year | Out |
| West Virginia | QB | Jarrett Brown | Shoulder | Probable |
