| School | Pos | Player | Injury | Status |
| Buffalo | RB | Ike Nduka | Ankle injury | Doubtful |
| Buffalo | WR | Naaman Roosevelt | Knee | Out |
| BYU | RB | Harvey Unga | Sparined ankle | Gametime Decision |
| Cal | RB | Jahvid Best | Concussion | Out |
| Florida Atlantic | QB | Rusty Smith | Shoulder, likely out for year | Out |
| Florida State | QB | Christian Ponder | Shoulder | Out |
| Fresno State | RB | Ryan Mathews | Concussion | Out |
| Georgia | WR | AJ Green | Shoulder | Out |
| Hawaii | QB | Bryant Moniz | Bruised ribs | Probable |
| Hawaii | WR | Greg Salas | Foot | Probable |
| Houston | WR | James Cleveland | Leg | Questionable |
| Idaho | QB | Nathan Enderle | Shoulder | Questionable |
| Illinois | QB | Juice Williams | Ankle | Doubftul |
| Iowa | QB | Ricky Stanzi | Ankle | Out |
| Iowa | RB | Brandon Wegher | Ribs | Doubtful |
| Kansas | RB | Jake Sharp | Calf | Probable |
| Kentucky | WR | Randall Cobb | Shoulder | Probable |
| UL-Lafayette | TE | Ladarius Green | Neck | Questionable |
| LSU | QB | Jordan Jefferson | Ankle | Probable |
| LSU | RB | Charles Scott | Clavicle, out for year | Out |
| Marshall | RB | Darius Marshall | Ankle | Doubtful |
| Marshall | TE | Cody Slate | Knee | Out |
| Missouri | WR | Jared Perry | Knee | Out |
| Navy | RB | Vince Murray | Shoulder | Questionable |
| Nebraska | TE | Mike McNeill | Undisclosed | Questionable |
| Northern Illinois | RB | Chad Spann | Shoulder | Questionable |
| Northern Illinois | RB | Meco Brown | Ankle | Probable |
| Notre Dame | TE | Kyle Rudolph | Shoulder, out for regular season | Probable |
| Ohio | WR | Taylor Price | Knee | Questionable |
| Ohio State | PK | Aaron Pettrey | Knee | Out |
| Oklahoma State | QB | Zac Robinson | Concussion | Probable |
| Oregon | TE | Ed Dickson | Flu symptoms | Probable |
| San Diego State | WR | Vincent Brown | Hand, likely out for season | Out |
| SMU | QB | Bo Levi Mitchell | Shoulder | Questionable |
| South Florida | WR | Carlton Mitchell | Leg | Doubtful |
| Texas Tech | QB | Steven Sheffield | Foot | Probable |
| Toledo | QB | Aaron Opelt | Shoulder | Questionable |
| Toledo | QB | Austin Dantin | Ankle | Questionable |
| Toledo | WR | Stephen Williams | Ankle | Probable |
| Troy | PK | Sam Glusman | Quad | Out |
| USC | TE | Anthony McCoy | Sprained Ankle | Questionable |
| USC | WR | Damian Williams | Sprained Ankle | Doubtful |
| Western Michigan | WR | Juan Nunez | Ankle | Questionable |
