A total of 53 college football players will be leaving school early for the 2010 NFL draft. Some of the bigger names leaving the college fantasy football world are Ryan Mathews, Dezmon Briscoe, Antonio Brown, Jahvid Best, Darius Marshall, Jimmy Clausen and Golden Tate.
2010 NFL Draft Early Entrants
| Player | Pos / School |
| Basped, Kevin | DE Nevada |
| Benn, Arrelious | WR Illinois |
| Berry, Eric | DB Tennessee |
| Best, Jahvid | RB California |
| Bowman, Navorro | LB Penn State |
| Briscoe, Dezmon | WR Kansas |
| Brown, Antonio | WR Central Michigan |
| Bryant, Dez | WR Oklahoma State |
| Bulaga, Bryan | T Iowa |
| Burnett, Morgan | DB Georgia Tech |
| Campbell, Bruce | T Maryland |
| Clausen, Jimmy | QB Notre Dame |
| Curran, Rennie | LB Georgia |
| Davis, Anthony | T Rutgers |
| Dunlap, Carlos | DE Florida |
| Dwyer, Jonathan | RB Georgia Tech |
| Franks, Dominique | DB Oklahoma |
| Geathers, Clifton | DE South Carolina |
| Gibson, Thaddeus | DE Ohio State |
| Gresham, Jermaine | TE Oklahoma |
| Griffen, Everson | DE Southern California |
| Gronkowski, Rob | TE Arizona |
| Haden, Joe | DB Florida |
| Hernandez, Aaron | TE Florida |
| Jackson, Kareem | DB Alabama |
| Jones, Chad | DB LSU |
| Jones, Reshad | DB Georgia |
| Joseph, Linval | DT East Carolina |
| Marshall, Darius | RB Marshall |
| Mathews, Ryan | RB Fresno State |
| McClain, Rolando | LB Alabama |
| McCoy, Gerald | DT Oklahoma |
| McKnight, Joe | RB Southern California |
| McNeal, Shawnbrey | RB SMU |
| Mitchell, Carlton | WR South Florida |
| Moore, Joshua | DB Kansas State |
| Morgan, Derrick | DE Georgia Tech |
| Norton, Jerell | DB Arkansas |
| Pierre-Paul, Jason | DE South Florida |
| Pouncey, Maurkice | C Florida |
| Price, Brian | DT UCLA |
| Rogan, Dennis | DB Tennessee |
| Snead, Jevan | QB Mississippi |
| Spievey, Amari | DB Iowa |
| Tate, Golden | WR Notre Dame |
| Thomas, Demaryius | WR Georgia Tech |
| Thomas, Earl | DB Texas |
| Warren, Donovan | DB Michigan |
| Williams, Damian | WR Southern California |
| Williams, Mike | WR Syracuse |
| Worilds, Jason | DE Virginia Tech |
| Wright, Major | DB Florida |
